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Studies on quinoline derivatives and related compounds. II. Synthesis of 5-substituted 1-ethyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

✍ Scribed by Hideo Agui; Toshiaki Komatsu; Takenari Nakagome


Book ID
112123466
Publisher
Journal of Heterocyclic Chemistry
Year
1975
Tongue
English
Weight
466 KB
Volume
12
Category
Article
ISSN
0022-152X

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A series of substituted 1-cyclopropyl-6-fluoro-1, 4-dihydro-5-methyl-4-oxo-3-quinoline carboxylic acids was synthesized and tested for their in vitro and in vivo antibacterial activity. The introduction of a methyl group at the 5-position of quinoline nucleus enhanced characteristically the antibact