A series of substituted 1-cyclopropyl-6-fluoro-1, 4-dihydro-5-methyl-4-oxo-3-quinoline carboxylic acids was synthesized and tested for their in vitro and in vivo antibacterial activity. The introduction of a methyl group at the 5-position of quinoline nucleus enhanced characteristically the antibact
✦ LIBER ✦
Synthesis and isomeric conversions of several 2-substituted 1,4-dihydro-4-oxo-3-quinolinecarboxylic acid derivatives
✍ Scribed by L. I. Kononov; G. A. Veinberg; É. É. Liepin'sh; I. V. Dipan; N. M. Sukhova; é. Lukevits
- Publisher
- Springer US
- Year
- 1988
- Tongue
- English
- Weight
- 560 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0009-3122
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## Abstract A one‐step ‘ring switching’ transformation of (__S__)‐3‐[(dimethylamino)methylidene]‐5‐(methoxycarbonyl)tetrahydrofuran‐2‐one (**4**) with 2‐pyridineacetic acid derivatives (**5–7**) and 2‐aminopyridines (**8, 9**) afforded the corresponding 3‐(4‐oxo‐4__H__‐quinolizinyl‐3)‐ **(15–17)**