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Synthesis of 3-(4-Oxo-4H-quinolizinyl-3) and 3-(4-Oxo-4H-pyridino[1,2-a]pyrimidinyl-3) substituted lactic acid derivatives

✍ Scribed by Marko Škof; Jurij Svete; Branko Stanovnik


Publisher
Journal of Heterocyclic Chemistry
Year
2000
Tongue
English
Weight
279 KB
Volume
37
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

A one‐step ‘ring switching’ transformation of (S)‐3‐[(dimethylamino)methylidene]‐5‐(methoxycarbonyl)tetrahydrofuran‐2‐one (4) with 2‐pyridineacetic acid derivatives (5–7) and 2‐aminopyridines (8, 9) afforded the corresponding 3‐(4‐oxo‐4__H__‐quinolizinyl‐3)‐ (15–17) and 3‐(4‐oxo‐4__H__‐pyridino[1,2‐a]pyrimidinyl‐3)‐2‐hydroxypropanoates (18, 19), respectively.


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