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Synthesis of 3-(4-Oxo-4H-quinolizinyl-3) and 3-(4-Oxo-4H-pyridino[1,2-a]pyrimidinyl-3) substituted lactic acid derivatives
✍ Scribed by Marko Škof; Jurij Svete; Branko Stanovnik
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2000
- Tongue
- English
- Weight
- 279 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
A one‐step ‘ring switching’ transformation of (S)‐3‐[(dimethylamino)methylidene]‐5‐(methoxycarbonyl)tetrahydrofuran‐2‐one (4) with 2‐pyridineacetic acid derivatives (5–7) and 2‐aminopyridines (8, 9) afforded the corresponding 3‐(4‐oxo‐4__H__‐quinolizinyl‐3)‐ (15–17) and 3‐(4‐oxo‐4__H__‐pyridino[1,2‐a]pyrimidinyl‐3)‐2‐hydroxypropanoates (18, 19), respectively.
📜 SIMILAR VOLUMES
## Abstract Reaction of 4__H__‐pyrimido[2,1‐__b__]benzothiazole‐2‐thiomethyl‐3‐cyano‐4‐one **(1)** with hydrazine hydrate/aryl hydrazine/heteryl hydrazine in the presence of anhydrous potassium carbonate and dimethyl formamide afforded 3‐amino‐4‐oxo‐(2__H__)/aryl/heteryl pyrazolo[3′,4′:4,5]pyrimido