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Synthesis and antibacterial activity of 2-substituted 6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids

✍ Scribed by Jae-Chul Jung; Shin Baek; Oee-Sook Park


Book ID
114018970
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
152 KB
Volume
56
Category
Article
ISSN
0014-827X

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✍ Hisashi Miyamoto; Hiroshi Yamashita; Hiraki Ueda; Hisashi Tamaoka; Kazunoli Ohmo πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 677 KB

A series of substituted 1-cyclopropyl-6-fluoro-1, 4-dihydro-5-methyl-4-oxo-3-quinoline carboxylic acids was synthesized and tested for their in vitro and in vivo antibacterial activity. The introduction of a methyl group at the 5-position of quinoline nucleus enhanced characteristically the antibact