Synthesis of 3-(β-D-ribofuranosyl)-2-flu
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Jasenka Matulic-Adamic; Leonid Beigelman
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Article
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1997
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Elsevier Science
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French
⚖ 224 KB
Pyridin-2-one C-nucleoside 13 was prepared in 7 steps from 2-fluoropyridine 1 and D-ribono-l,4-1actone 2. The successful approach to ~i-ribofuranosides 12 and 13 consisted of the reductive opening of the furanose ring of hemiacetal 3 followed by intramolecular Mitsunobu cyclization.