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Synthesis of 3-(β-D-ribofuranosyl)-2-fluoropyridine and 3-(β-D-ribofuranosyl)-pyridin-2-one

✍ Scribed by Jasenka Matulic-Adamic; Leonid Beigelman

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
224 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Pyridin-2-one C-nucleoside 13 was prepared in 7 steps from 2-fluoropyridine 1 and D-ribono-l,4-1actone 2. The successful approach to ~i-ribofuranosides 12 and 13 consisted of the reductive opening of the furanose ring of hemiacetal 3 followed by intramolecular Mitsunobu cyclization.

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