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Synthesis of 5-(β-D-ribofuranosyl)-pyridin-2-one: A “deletion-modiffied” analogue of uridine

✍ Scribed by Jasenka Matulic-Adamic; Leonid Beigelman

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
230 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

Pyridin-2-one C-nucleoside 2 was prepared using several different approaches.

The most efficient pathway utilized the condensation of 2,3,5-tri-O-benzyl-D-ribono-l,4lactone (4) and 2-(benzyloxy)-5-bromopyridine (5), followed by deoxygenation with Et3SiH/BF3.Et20 and removal of the benzyl protecting groups.

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