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Synthesis of 2-(β-D-ribofuranosyl)[1,3,5]triazines

✍ Scribed by Timothy A. Riley; William J. Hennen; N. Kent Dalley; Bruce E. Wilson; Roland K. Robins


Book ID
112128414
Publisher
Journal of Heterocyclic Chemistry
Year
1986
Tongue
English
Weight
478 KB
Volume
23
Category
Article
ISSN
0022-152X

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Synthesis of 3-(β-D-ribofuranosyl)-2-flu
✍ Jasenka Matulic-Adamic; Leonid Beigelman 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 224 KB

Pyridin-2-one C-nucleoside 13 was prepared in 7 steps from 2-fluoropyridine 1 and D-ribono-l,4-1actone 2. The successful approach to ~i-ribofuranosides 12 and 13 consisted of the reductive opening of the furanose ring of hemiacetal 3 followed by intramolecular Mitsunobu cyclization.