A Synthesis of 3-Phenylpiperidines
โ Scribed by Koelsch, C. F.
- Book ID
- 119962554
- Publisher
- American Chemical Society
- Year
- 1943
- Tongue
- English
- Weight
- 400 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
The syntheses of 1-methyl-3-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-piperidinol and 1-methyl-3(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propanoyloxypiperidine are described. Preliminary pharmacological testing showed these compounds to be weakly active in the writhing test.
A catalytic highly enantioselective (99% ee) preparation of N-tert-butyloxycarbonyl-(2S,3S)-3-hydroxy-2-phenyl-piperidine and N-tert-butyloxycarbonyl-(2S)-2-phenyl-piperidin-3-one was developed using an intramolecular epoxide opening followed by ring expansion. The cis-epoxide starting material was