3-Alkyl-3-phenylpiperidine Derivatives as Analgesics
โ Scribed by Kugita, Hiroshi; Inoue, Hirozumi; Oine, Toyonari; Hayashi, Goro; Nurimoto, Seiichi
- Book ID
- 127335564
- Publisher
- American Chemical Society
- Year
- 1964
- Tongue
- English
- Weight
- 446 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0022-2623
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๐ SIMILAR VOLUMES
Conformational energy calculations have been performed on 3-phenylpiperidine and 3-phenylpyrrolidine opioids using the MM2 method. Phenyl equatorial conformers were found to be preferred for 1,2,3-trimethyl-3-phenylpiperidines while phenyl axial conformers were preferred for the 2-demethyl derivativ
The syntheses of 1-methyl-3-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-piperidinol and 1-methyl-3(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propanoyloxypiperidine are described. Preliminary pharmacological testing showed these compounds to be weakly active in the writhing test.