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A synthesis of [14C] progabide®- a new anticonvulsant

✍ Scribed by J. Allen; D. Giffard

Book ID
102368818
Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
236 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Progabide®, 4‐[[(4‐chlorophenyl) (5‐fluoro‐2‐hydroxyphenyl)‐methylene]amino] butanamide, labelled individually with carbon‐14 in the butanamide side‐chain and in the imino carbon were synthesised for pharmacokinetic and metabolism studies. The former from potassium [^14^C] cyanide and the latter from barium [^14^C] carbonate in overall radiochemical yields of 33.8 and 42.2 % respectively.

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