## Abstract Carbon‐14 labeled 3,5‐dihydro‐5‐methyl‐1(2H)‐isoquinolinone, a potent inhibitor of poly(ADP‐ribose) polymerase (ADPRP) was prepared from 1‐bromo‐2‐methylbenzene in 7.8 % overall yield. The C‐14 label was introduced from Ba^14^CO~3~ via metal‐halogen exchange and carboxylation reactions.
Synthesis of a new anticonvulsant labelled with 14C: 1, 4-dihydro-1-[4′-(ethylaminoacetyl)-aminophenyl]-3 (2H)-isoquinolinone
✍ Scribed by E. Koltai; D. Bánfi; L. Hazai; Gy. Deák
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 336 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
1,4-Dihyd~~-l-[4~-(e thylaminoace ty1)-aminophenyl] --3(2H)-ieoquinolinone wae labelled with 14C in two different poeitiono: in one caee in position 3 of the ieoquinoline ring, in the other c a m in the carbonyl group of the ethylaminoacetyl moiety.
📜 SIMILAR VOLUMES
2-14C-oxazepam (z) d 4 C -(+)and -(-1 -7-chloro-l--methyl-5-phenyl-1,3,4,5-tetrahydro-3H-l,4-benzodiazepine-2--one (s and 2) as well as 2-14C-7-chloro-4-carbamoyl-l-methyl--5-phenyl-1,3,4,5-tetrahydro-3H-l,4-benzodiazepine-2-one (9-1 were synthesised from ~arbobenzoxy-glycine-1-~~C. The overall rad
## Abstract The synthesis from carbon‐^14^C dioxide of 1, 3‐dihydro‐1‐methyl‐7‐nitro‐5‐phenyl‐2H‐1, 4‐benzodiazepin‐2‐one‐5‐^14^C (I) for use in metabolic studies has been described. The synthesis was achieved by the sequence shown in figure 1. The overall yield of labelled nimetazepam (I) was near
## Abstract A group of radioactive 1,4‐benzodiazepine derivatives have been synthesized from glycine‐1‐^14^C. The subject compounds are labeled with carbon‐14 in the 2‐position of the 1,4‐benzodiazepine ring system.