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A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease

โœ Scribed by Geoffroy Laumet; Vincent Petitprez; Adeline Sillaire; Anne-Marie Ayral; Franck Hansmannel; Julien Chapuis; Didier Hannequin; Florence Pasquier; Elio Scarpini; Daniela Galimberti; Corinne Lendon; Dominique Campion; Philippe Amouyel; Jean-Charles Lambert


Book ID
116771806
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
115 KB
Volume
468
Category
Article
ISSN
0304-3940

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## Abstract The neuropathology of Alzheimer's disease (AD) is characterized by intracellular neurofibrillary tangles and the extracellular deposition of ฮฒโ€amyloid (Aฮฒ) in senile plaques. Aฮฒ has been shown to mediate neurodegenerative and inflammatory changes associated with amyloid plaques, althoug