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Association study of the ADAM12 and SH3MD1 genes with the risk of developing Alzheimer's disease

✍ Scribed by Laumet, Geoffroy; Petitprez, Vincent; Ayral, Anne-Marie; Hansmanel, Franck; Chapuis, Julien; Hannequin, Didier; Pasquier, Florence; Galimberti, Daniela; Scarpini, Elio; Lendon, Corinne; Campion, Dominique; Amouyel, Philippe; Lambert, Jean-Charles


Book ID
122540622
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
64 KB
Volume
5
Category
Article
ISSN
1552-5260

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## Abstract The neuropathology of Alzheimer's disease (AD) is characterized by intracellular neurofibrillary tangles and the extracellular deposition of β‐amyloid (AΞ²) in senile plaques. AΞ² has been shown to mediate neurodegenerative and inflammatory changes associated with amyloid plaques, althoug