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P1-284: Interaction between ADAM12 and SH3MD1 may confer susceptibility to late-onset Alzheimer’s disease

✍ Scribed by Julie Williams; Denise Harold; Luke Jehu; Dragana Turic; Paul Hollingworth; Valentina Moskvina; Carol Brayne; David Rubensztein; Simon Lovestone; John Powell; Lesley Jones; Michael O’Donovan; Michael Owen

Book ID
118462733
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
64 KB
Volume
2
Category
Article
ISSN
1552-5260

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Interaction between the ADAM12 and SH3MD
Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease
✍ D. Harold; L. Jehu; D. Turic; P. Hollingworth; P. Moore; P. Summerhayes; V. Mosk 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 75 KB 👁 2 views

## Abstract The neuropathology of Alzheimer's disease (AD) is characterized by intracellular neurofibrillary tangles and the extracellular deposition of β‐amyloid (Aβ) in senile plaques. Aβ has been shown to mediate neurodegenerative and inflammatory changes associated with amyloid plaques, althoug