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Association between a variant of the sigma-1 receptor gene and Alzheimer's disease

✍ Scribed by Ágnes Fehér; Anna Juhász; Anna László; János Kálmán Jr.; Magdolna Pákáski; János Kálmán; Zoltán Janka

Book ID: 116774134
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 176 KB
Volume: 517
Category: Article
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2012.04.046

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## Abstract A number of studies suggest that brain cholesterol metabolism may play a role in Alzheimer's disease (AD) development, probably through modulation of amyloid beta production. The discovery that apolipoprotein E (__APOE__) ε4 allele is a risk factor for sporadic AD raises the possibility