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A strategy simplifying site-directed mutagenesis in the CD4-binding region of HIV gp 120

✍ Scribed by Anna Hemming; L. Lundberg; S. Olofsson

Publisher
Springer Vienna
Year
1989
Tongue
English
Weight
582 KB
Volume
107
Category
Article
ISSN
1432-8798

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LAV44 and LAV15 (lymphadenopathy-associated virus) peptides of the CD4-binding region of gp 120 per se bind to the CD4 receptor (Reed and Kinzel, Biochemistry 30: 4521-4528, 1991; Lasky et al., Cell 50:975-985, 1987). Depending on the environment, the LAV peptides exhibit the ability to switch coope