Characterization of T cell-expressed chimeric receptors with antibody-type specificity for the CD4 binding site of HIV-1 gp120

Structure of the LAV6 peptide: A nucleat

Structure of the LAV6 peptide: A nucleation site for the correct receptor-induced refolding of the CD4-binding domain of HIV1 gp 120

✍ Almut Lindemann; Volker Kinzel; Paul Rösch; Jennifer Reed 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 181 KB

LAV44 and LAV15 (lymphadenopathy-associated virus) peptides of the CD4-binding region of gp 120 per se bind to the CD4 receptor (Reed and Kinzel, Biochemistry 30: 4521-4528, 1991; Lasky et al., Cell 50:975-985, 1987). Depending on the environment, the LAV peptides exhibit the ability to switch coope