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Engineering a CD4 mimetic inhibiting the binding of the human immunodeficiency virus-1 (HIV-1) envelope glycoprotein gp120 to human lymphocyte CD4 by the transfer of a CD4 functional site to a small natural scaffold

✍ Scribed by Eugenia Drakopoulou; Jean Vizzavona; Claudio Vita

Publisher
Springer Netherlands
Year
1998
Tongue
English
Weight
365 KB
Volume
5
Category
Article
ISSN
1573-3149

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Lateral diffusion of CD4 on the surface of a human neoplastic T-cell line probed with a fluorescent derivative of the envelope glycoprotein (gp120) of human immunodeficiency virus type 1 (HIV-1)
✍ Ranajit Pal; B. C. Nair; George M. Hoke; M. G. Sarngadharan; Michael Edidin πŸ“‚ Article πŸ“… 1991 πŸ› John Wiley and Sons 🌐 English βš– 862 KB

The envelope glycoprotein (gpl20) of HIV-1 was labeled with fluorescein by using 6- [4,6-dichlorotriazinyl]aminofluorescein. The labeled glycoprotein was found to bind to CD4-positive CEM cells. Monoclonal antibody OKT4a but not OKT4 blocked this binding. Similar specific binding of fluorescein-labe