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A Solution and Solid State Study on 2-Hydroxypropyl-β-Cyclodextrin Complexation with Hyodeoxycholic Acid

✍ Scribed by M. A. Vandelli; B. Ruozi; F. Forni; A. Mucci; G. Salvioli; E. Galli


Book ID
110259486
Publisher
Springer Netherlands
Year
2000
Tongue
English
Weight
165 KB
Volume
37
Category
Article
ISSN
0923-0750

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The interaction between spironolactone (Sp) and hydroxypropyl-b-cyclodextrin (HPbCD) has been investigated in aqueous solution and in the solid state. Phase solubility studies indicate that the complex is formed with possible stoichiometry of 1:1 and association constant of 9806 M À1 . Differential