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Comparative study of ibuproxam complexation with amorphous β-cyclodextrin derivatives in solution and in the solid state

✍ Scribed by Paola Mura; Naima Zerrouk; M.Teresa Faucci; Francesca Maestrelli; Chantal Chemtob


Book ID
117639352
Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
823 KB
Volume
54
Category
Article
ISSN
0939-6411

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Inclusion complexation between celecoxib, a specific cyclooxygenase II inhibitor, and beta-cyclodextrin (b-CD) was studied in solution and solid state. Drug cyclodextrin complexes were prepared by spray drying while physical mixtures were obtained by simple blending. Inclusion complexes were charact