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Inclusion complexes of 5-flucytosine with β-cyclodextrin and hydroxypropyl-β-cyclodextrin: characterization in aqueous solution and in solid state

✍ Scribed by Mariana Spulber; Mariana Pinteala; Adrian Fifere; Valeria Harabagiu; Bogdan C. Simionescu


Publisher
Springer Netherlands
Year
2008
Tongue
English
Weight
533 KB
Volume
62
Category
Article
ISSN
0923-0750

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✍ Omid Rajabi; Farnoosh Tayyari; Roshanak Salari; Sayyed Faramarz Tayyari 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 646 KB

The interaction between spironolactone (Sp) and hydroxypropyl-b-cyclodextrin (HPbCD) has been investigated in aqueous solution and in the solid state. Phase solubility studies indicate that the complex is formed with possible stoichiometry of 1:1 and association constant of 9806 M À1 . Differential