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Study of interaction of spironolactone with hydroxypropyl-β-cyclodextrin in aqueous solution and in solid state

✍ Scribed by Omid Rajabi; Farnoosh Tayyari; Roshanak Salari; Sayyed Faramarz Tayyari

Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 646 KB
Volume: 878
Category: Article
ISSN: 0022-2860
DOI: 10.1016/j.molstruc.2007.07.043

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✦ Synopsis

The interaction between spironolactone (Sp) and hydroxypropyl-b-cyclodextrin (HPbCD) has been investigated in aqueous solution and in the solid state. Phase solubility studies indicate that the complex is formed with possible stoichiometry of 1:1 and association constant of 9806 M À1 . Differential scanning calorimetry (DSC) gave evidence for the formation of the complex. The details of Sp/HPbCD molecular interaction were analyzed by Fourier transform infrared (FTIR) and Raman spectroscopy. The characterization studies confirmed that the C@O groups of the six-member ring and acetylthio group of Sp interacts with the hydroxyl groups inside and outside the cavity of HPbCD through formation of hydrogen bonds.

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