✦ LIBER ✦

A solid-phase equivalent of van Leusen's TosMIC, and its application in oxazole synthesis

✍ Scribed by Bheemashankar A. Kulkarni; A. Ganesan

Book ID: 104261832
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 210 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)01049-7

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✦ Synopsis

Polystyrene-SH resin, prepared from Merrifield resin in two steps, was converted to polystyrene-SO2-CH2-NC in three steps. This resin functions as a solid-phase equivalent of p-tolylsulfonylmethyl isocyanide (TosMIC). Thus, reaction with aromatic aldehydes and tetrabutylammonium hydroxide as base yields 5-aryloxazoles.

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