## Abstract A rapid synthesis of 2โdeoxyโ2โfluoroโDโglucose **(3)** from xenon difluoride is described. Reaction of 3,4,6โtriโOโacetylโDโglucal **(1)** with xenon difluoride in ethyl ether in the presence of BF~3~ยทOEt~2~ for 20 minutes gave 2โdeoxyโ2โfluoroโ 3,4,6โtriโOโacetylโDโglucopyranosyl fluo
A simple synthesis of 2-deoxy-2-fluoro-d-galactose using xenon difluoride
โ Scribed by Christoph C. Geilen; Nikolaus Loch; Werner Reutter; Konrad Seppelt; Franz Oberdorfer
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- French
- Weight
- 242 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
A nucleophilic radiofluorination of methyl 3,4-0-isopropylidene-2-0-(trif luoromethanesulfonyl) -6-O-trityl-/3-D-talopyranoside (1) with aninopolyether Hydrolysis of 2 with 6N HCl followed by passage through an ion retardation resin column and a neutral alumina column gave 2-deoxy-2-[18F1 f luoro-
SUlMARY 2-Deoxy-2-[1eFlfluoro-D-galactose was prepared using gaseous [ ' a F] acetyl hypofluorite or [ l a FIFz and tri-0-acetyl-0-galactal as substrate. The product was obtained in a surprisingly high epimeric purity ( > g o % ) , even with [ l a P I F ~ as fluorinating reagent, as demonstrated by
18F labelled compounds. Thus, a synthetic route to ("F)2-Deoxy-2-fluoro-~glucose was studied which should run as simple and hot-cell-friendly as possible and shc~uld deliver the sugar with high yield and free of diastereomers, even by use of high I8F acitivities