A simple synthesis of 18F-labelled 5-fluorouracil using acetylhypofluorite
โ Scribed by M. Diksic; S. Farrokhzad; Y.L. Yamamoto; W. Feindel
- Book ID
- 116083914
- Publisher
- Elsevier Science
- Year
- 1984
- Weight
- 158 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0047-0740
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๐ SIMILAR VOLUMES
## 5-[18F] Fluorouracil was prepared by direct fluorination of uracil in acetic acid using [18F]F2 diluted in neon. The labelled product was obtained with a purity of 299% following preparative HPLC. Quality control consisted of two different and improved HPLC procedures combined with high resolut
Three 18F-labeled pyrimidines, 18F-5-fluorouridine (18F-5-FUR), 18F-5-fluorouracil (18F-5-FU), and 18F-5-fluorodeoxyuridine (18F-5-FdUR), were examined regarding tissue distribution and tumor uptake in ascitic hepatoma AH109A-bearing rats. The differential absorption ratios of tumors of 18F-5-FUR, 1