Studies on18F-labeled pyrimidines. Tumor uptakes of18F-5-fluorouracil,18F-5-fluorouridine, and18F-5-fluorodeoxyuridine in animals

✍ Scribed by Yoshinao Abe; Hiroshi Fukuda; Kiichi Ishiwata; Seiro Yoshioka; Kenji Yamada; Satoshi Endo; Kazuo Kubota; Tachio Sato; Taiju Matsuzawa; Toshihiro Takahashi; Tatsuo Ido

• Publisher: Springer
• Year: 1983
• Tongue: English
• Weight: 595 KB
• Volume: 8
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00522517

✦ Synopsis

Three 18F-labeled pyrimidines, 18F-5-fluorouridine (18F-5-FUR), 18F-5-fluorouracil (18F-5-FU), and 18F-5-fluorodeoxyuridine (18F-5-FdUR), were examined regarding tissue distribution and tumor uptake in ascitic hepatoma AH109A-bearing rats. The differential absorption ratios of tumors of 18F-5-FUR, 18F-5-FU, and 18F-5-FdUR were 0.75 +/- 0.21, 0.92 +/- 0.15, and 0.96 +/- 0.24 at 30 min, and 0.37 +/- 0.09, 0.64 +/- 0.34, and 0.60 +/- 0.17 at 120 min, respectively. The tumor-to-organ ratios obtained with three radiopharmaceuticals, especially with blood, heart, lung, muscle, and brain were high and these ratios increased with time. The tumor-to-organ ratios obtained with 18F-5-FdUR were always 1.3-4 times higher than 18F-5-FU and 18F-5-FUR. We concluded that 18F-5-FdUR was a suitable radiopharmaceutical for tumor imaging. Positron emission tomography of a rabbit tumor located on the chest with 18F-5-FdUR clearly showed the tumor within 1 h.