A convenient, high-yield synthesis of [18F]4-fluoroantipyrine using [18F]acetylhypofluorite
โ Scribed by Mirko Diksic; Pasquale Diraddo
- Book ID
- 107769333
- Publisher
- Elsevier Science
- Year
- 1985
- Weight
- 260 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0020-708X
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๐ SIMILAR VOLUMES
The synthesis of 4-[18F]fluoroantipyrine (1) and its biodistribution in mice are described. Compound 1 was synthesized either by direct fluorination of antipyrine with [18F]F2 or CH3CO2 18F, or by an isotopic exchange method. While direct fluorination of antipyrine with [18F]F2 gave compound 1 in ab
A protected 6-trimethylstannyl dopa derivative 6 has been synthesized for the first time as a precursor for the preparation of 6-[18F]fluoro-L-dopa. The tin derivative 6 readily reacted with electrophilic radiofluorinating agents such as [18F]F2 and [18F]AcOF. The [18F]fluoro intermediate 7 was easi