𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A simple oxazolidine linker for solid-phase synthesis of peptide aldehydes

✍ Scribed by Wu Kang; Weiguo Wang; XiaoXia Zhi; Bo Zhang; Ping Wei; HongYan Xu


Book ID
113496417
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
286 KB
Volume
22
Category
Article
ISSN
0960-894X

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Acetophenone-based linker for solid-phas
✍ Chinh T. Bui; Andrew M. Bray; Thao Nguyen; Francesca Ercole; Firas Rasoul; Wayne πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 126 KB πŸ‘ 2 views

A new and cost-effective linker for the generation of carboxylic acid end groups on Multipin supports (SynPhaseβ„’ crowns) has been developed. Synthesis of the linker was based on modification of grafted polystyrene (PS) crowns to generate a hydroxyethyl moiety which is acid labile in 10 -20% trifluor

Simple and efficient solid-phase synthes
✍ Dominique LeliΓ¨vre; Hadjila Chabane; AgnΓ¨s Delmas πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 217 KB

We describe an efficient solid-phase synthesis of C-terminal peptide aldehyde. Making use of the stability of the PAM linker towards both acid and base conditions, a pentapeptide was synthesized starting from a PAM resin according to Fmoe/tBu chemistry. The side-chains were deprotected by TFA. The p

A simple linker for the attachment of al
✍ Nicholas J. Ede; Andrew M. Bray πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 226 KB

A simple linker has been developed for the attachment of ahtehyde fimctionality. The aldehyde substrate is condensed with a support-bound serine or threonine to give an oxazolidine. The oxazolidine linker is stable to the conditions of Fntoc peptide synthesis, inchtding TFA treatment, but is cleaved