A tartaric acid-based linker was elaborated on an amino PEGA resin for the synthesis of C-terminal cx-oxoaldehydes. A solid phase periodic oxidation allowed the formation of the glyoxylyl moiety and the separation of the final product from the solid support.
A Novel Oxazolidine Linker for the Synthesis of Peptide Aldehydes
β Scribed by Michinori Tanaka; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii
- Publisher
- Springer Netherlands
- Year
- 2007
- Tongue
- English
- Weight
- 349 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1573-3149
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A novel linker for the generation of alkyl-, acyl-and arylguanidines as an attachment point in solid phase synthesis has been developed. Introduction of a suitably functionalized thiourea to Wang resin via a carbamate linkage, followed by displacement of sulfur with a 1 Β° or 2 Β° amine affords resin
A practical strategy for solid phase synthesis of peptide aldehydes is described. An olefin linker is constructed using Wittig chemistry, after peptide synthesis ozonolytic treatment of the linker and subsequent workup with dimethyl sulphide results in facile isolation of peptide aldehydes. The prin