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A new linker for the synthesis of C-terminal peptide α-oxo-aldehydes

✍ Scribed by Jean-Sébastien Fruchart; Hélène Gras-Masse; Oleg Melnyk

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
268 KB
Volume
40
Category
Article
ISSN
0040-4039

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✦ Synopsis

A tartaric acid-based linker was elaborated on an amino PEGA resin for the synthesis of C-terminal cx-oxoaldehydes. A solid phase periodic oxidation allowed the formation of the glyoxylyl moiety and the separation of the final product from the solid support.

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