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A practical method for the combinatorial synthesis of peptide aldehydes

✍ Scribed by Beverley J. Hall; John D. Sutherland

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
171 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A practical strategy for solid phase synthesis of peptide aldehydes is described. An olefin linker is constructed using Wittig chemistry, after peptide synthesis ozonolytic treatment of the linker and subsequent workup with dimethyl sulphide results in facile isolation of peptide aldehydes. The principle is demonstrated by synthesis of a 3x3x3 array of 27 tripeptide aldehydes.

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