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Optimization of the synthesis of peptide combinatorial libraries using a one-pot method

✍ Scribed by Lee W. Herman; George Tarr; Steven A. Kates


Publisher
Springer
Year
1997
Tongue
English
Weight
974 KB
Volume
2
Category
Article
ISSN
1381-1991

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A practical method for the combinatorial
✍ Beverley J. Hall; John D. Sutherland πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 171 KB

A practical strategy for solid phase synthesis of peptide aldehydes is described. An olefin linker is constructed using Wittig chemistry, after peptide synthesis ozonolytic treatment of the linker and subsequent workup with dimethyl sulphide results in facile isolation of peptide aldehydes. The prin