A method for calculating the mean residence times of metabolites in the body, systemic circulation, and peripheral tissue is described. The calculations require the AUC, AUMC, and derivatives of the plasma concentration versus time curves of the metabolite and its precursor. The method is applicable
A simple method for obtaining the mean residence time of metabolites in the body
β Scribed by Peter Veng-Pedersen
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 158 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0022-3549
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π SIMILAR VOLUMES
The evaluation of mean residence times of drugs and metabolites provides a simple measure of the tendency for such substances to remain in various parts of the body.'-7 Most attention has been given to the evaluation of the mean residence times of the parent drug'-' although it is often of interest
A general method for calculating the mean transit times and distribution rate parameters is described. The calculations require the AUC, AUMC, and derivatives of the plasma concentration profiles of the metabolites and its precursor. The method is applicable to catenary metabolites with any precurso