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A method for calculating the mean transit times and distribution rate parameters of metabolites without separate intravenous administration of metabolite

โœ Scribed by Haiyung Cheng


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
307 KB
Volume
81
Category
Article
ISSN
0022-3549

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๐Ÿ“œ SIMILAR VOLUMES


A general method for calculating the mea
โœ Haiyung Cheng ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 341 KB ๐Ÿ‘ 2 views

A general method for calculating the mean transit times and distribution rate parameters is described. The calculations require the AUC, AUMC, and derivatives of the plasma concentration profiles of the metabolites and its precursor. The method is applicable to catenary metabolites with any precurso

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The evaluation of mean residence times of drugs and metabolites provides a simple measure of the tendency for such substances to remain in various parts of the body.'-7 Most attention has been given to the evaluation of the mean residence times of the parent drug'-' although it is often of interest