A method for calculating the mean transit times and distribution rate parameters of metabolites without separate intravenous administration of metabolite
โ Scribed by Haiyung Cheng
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 307 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
A general method for calculating the mean transit times and distribution rate parameters is described. The calculations require the AUC, AUMC, and derivatives of the plasma concentration profiles of the metabolites and its precursor. The method is applicable to catenary metabolites with any precurso
The evaluation of mean residence times of drugs and metabolites provides a simple measure of the tendency for such substances to remain in various parts of the body.'-7 Most attention has been given to the evaluation of the mean residence times of the parent drug'-' although it is often of interest