✦ LIBER ✦

A Simple High Performance Liquid Chromatography/Ionspray Tandem Mass Spectrometry Method for the Direct Determination of Paraquat and Diquat in Water

✍ Scribed by Julie C. Marr; James B. King

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 106 KB
Volume: 11
Category: Article
ISSN: 0951-4198
DOI: 10.1002/(sici)1097-0231(199703)11:5<479::aid-rcm874>3.0.co;2-u

No coin nor oath required. For personal study only.

✦ Synopsis

A method has been developed for the direct determination of paraquat and diquat in water samples. No sample preparation was required and analysis was done using high performance liquid chromatography coupled with ionspray tandem mass spectrometry. Heptafluorobutyric acid was used as the ion-pair agent. Further improvements in this method included the incorporation of an internal standard (caffeine). Using this method, detection limits of 5 and 1 µg/L were obtained for paraquat and diquat respectively. Recoveries were consistently > 90% with relative standard deviations of < 10% over the concentration range 5-100 µg/L. To our knowledge, this method is the first application of ionspray tandem mass spectrometry, and the first to use heptafluorobutyric acid as an ion-pair reagent, for the analysis of paraquat and diquat.

📜 SIMILAR VOLUMES

Collision-induced dissociation of cortic

Collision-induced dissociation of corticosteroids in electrospray tandem mass spectrometry and development of a screening method by high performance liquid chromatography/tandem mass spectrometry

✍ Jean-Philippe Antignac; Bruno Le Bizec; Fabrice Monteau; Frédéric Poulain; Franç 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 114 KB 👁 2 views

A screening method based on liquid chromatography/electrospray tandem mass spectrometry was developed in order to control the illegal use of corticosteroids as growth promoters in cattle. The objective was the detection of low residue levels of corticosteroids or metabolites in biological matrices.

Liquid–liquid extraction procedure for t

Liquid–liquid extraction procedure for trace determination of cyclophosphamide in human urine by high-performance liquid chromatography tandem mass spectrometry

✍ Cristina Sottani; Roberta Turci; Luigi Perbellini; Claudio Minoia 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 132 KB 👁 1 views

A sensitive, specific and accurate high performance liquid chromatography/ionspray-tandem mass spectrometry procedure (HPLC/MS/MS) has been developed to quantify cyclophosphamide in human urine from hospital personnel involved in drug preparation and administration of antineoplastic alkylating agent

High Performance Liquid Chromatography/A

High Performance Liquid Chromatography/Atmospheric Pressure Chemical Ionization-Mass Spectrometry for the Determination of Carotenoids

✍ Philip A. Clarke; Karen A. Barnes; James R. Startin; Frank I. Ibe; Martin J. She 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB 👁 2 views

The performance of electrospray ionization and atmospheric pressure chemical ionisation (APCI) for the analysis of carotenoids was investigated. On our instrument, APCI produced spectra which were readily interpreted, and the positive-ion mode proved applicable to all of the compounds. The separatio

A simple liquid–liquid extraction with h

A simple liquid–liquid extraction with hexane for low-picogram determination of drugs and their metabolites in plasma by high-performance liquid chromatography with positive ion electrospray tandem mass spectrometry

✍ Yuan-Qing Xia; Daisy B. Whigan; Mohammed Jemal 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 246 KB 👁 2 views

Four sensitive, specific and accurate methods, based on high-performance liquid chromatography (HPLC) with positive ion electrospray tandem mass spectrometry (MS/MS) coupled with liquid-liquid extraction (LLE), have been developed and validated for the low-picogram determination of two drug candidat

High performance liquid chromatography m

High performance liquid chromatography mobile phase composition optimization for the quantitative determination of a carboxylic acid compound in human plasma by negative ion electrospray high performance liquid chromatography tandem mass spectrometry

✍ Mohammed Jemal; Zheng Ouyang; Deborah S. Teitz 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 100 KB 👁 2 views

A systematic investigation was undertaken to study the effects of varying concentrations of additives in the acetonitrile/water high performance liquid chromatography mobile phase, especially formic acid and ammonium formate, on the negative ion electrospray response of a carboxylic acid compound. T

The need for adequate chromatographic se

The need for adequate chromatographic separation in the quantitative determination of drugs in biological samples by high performance liquid chromatography with tandem mass spectrometry

✍ Mohammed Jemal; Yuan-Qing Xia 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 128 KB 👁 2 views

This work describes real examples of classes of drugs (drug candidates) whose quantitative determination in biological matrices by high performance liquid chromatography with electrospray tandem mass spectrometry (LC/MS/MS) may be hampered by interferences from drug-related biotransformation product