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A simple, efficient synthesis of 3′-D3-mevalonic acid

✍ Scribed by Douglas R. Hawkins; Melvin Calvin

Book ID
102375710
Publisher
John Wiley and Sons
Year
1987
Tongue
French
Weight
218 KB
Volume
24
Category
Article
ISSN
0022-2135

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✦ Synopsis

3'-D3-Mevalonic acid was required to study triterpenoid biosynthesis. It was synthesized by a simple route in a 24% yield from D3-acetic acid-D. The product was characterized as the crystalline salt: N,N'-dibenzylethylenediammonium bis-(3,5-dihydroxy-3-(D3-methyl)-pentanoate) and was shown by mass spectroscopy and H-NMR to be essentially 100 atom% deuterium labelled.

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