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Synthesis of DL-3,5-Dihydroxy-3-methylpentanoic Acid (Mevalonic Acid)

โœ Scribed by Hoffman, Carl H.; Wagner, Arthur F.; Wilson, Andrew N.; Walton, Edward; Shunk, Clifford H.; Wolf, Donald E.; Holly, Frederick W.; Folkers, Karl


Book ID
125530191
Publisher
American Chemical Society
Year
1957
Tongue
English
Weight
442 KB
Volume
79
Category
Article
ISSN
0002-7863

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A simple, efficient synthesis of 3โ€ฒ-D3-m
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3'-D3-Mevalonic acid was required to study triterpenoid biosynthesis. It was synthesized by a simple route in a 24% yield from D3-acetic acid-D. The product was characterized as the crystalline salt: N,N'-dibenzylethylenediammonium bis-(3,5-dihydroxy-3-(D3-methyl)-pentanoate) and was shown by mass s