A Simple and Improved Correction for Population Stratification in Case-Control Studies
✍ Scribed by Michael P. Epstein; Andrew S. Allen; Glen A. Satten
- Book ID
- 117855186
- Publisher
- American Society of Human Genetics
- Year
- 2007
- Tongue
- English
- Weight
- 137 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/516842
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📜 SIMILAR VOLUMES
## Abstract Hidden population substructure can cause population stratification and lead to false‐positive findings in population‐based genome‐wide association (GWA) studies. Given a large panel of markers scanned in a GWA study, it becomes increasingly feasible to uncover the hidden population subs
## Abstract Genome‐wide association studies are helping to dissect the etiology of complex diseases. Although case‐control association tests are generally more powerful than family‐based association tests, population stratification can lead to spurious disease‐marker association or mask a true asso