A Simple and Efficient New Approach to the Total Synthesis of (±)-4-Amino-3-(4-chlorophenyl)-butyric Acid (Baclofen). -A new approach to the total synthesis of Baclofen (VI) involving the ( 2 + 2) cycloaddition between dichloroketene, generated from trichloroacetyl chloride (II), and olefin (I) as
A Simple and Efficient New Approach to the Total Synthesis of (±)-4-Amino-3-(4-Chlorophenyl)-Butyric Acid (BACLOFEN)
✍ Scribed by Coelho, Fernando; de Azevedo, Mariangela B. M.; Boschiero, Roberta; Resende, Patrícia
- Book ID
- 120283758
- Publisher
- Taylor and Francis Group
- Year
- 1997
- Tongue
- English
- Weight
- 315 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0039-7911
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The synthesis of the title compound is described. It involves base catalyzed substitution of deuterium for hydrogen in 3-p- -chlorophenylglutaric acid which is subsequently transformed to baclofen. The overall yield is 80%. ## INTRODUCTION AND DISCUSSION In order to develop a mass fragmentographi
## Abstract Two preparations of carbon‐14 labelled 4‐amino‐3‐(4‐chlorophenyl)‐butyric acid are described : First, the label is introduced in the 3‐position of the butyric acid chain in nine steps, starting from ^14^CO~2~. The total radiochemical yield is 30%, calculated from the first labelled inte