Synthesis and Pharmacology of the Baclofen Homologues 5-Amino-4-(4-chlorophenyl)pentanoic Acid and the R - and S -Enantiomers of 5-Amino-3-(4-chlorophenyl)pentanoic Acid
β Scribed by Karla, Rolf; Ebert, Bjarke; Thorkildsen, Christian; Herdeis, Claus; Johansen, Tommy N.; Nielsen, Birgitte; Krogsgaard-Larsen, Povl
- Book ID
- 120494774
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 98 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-2623
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π SIMILAR VOLUMES
The synthesis of the title compound is described. It involves base catalyzed substitution of deuterium for hydrogen in 3-p- -chlorophenylglutaric acid which is subsequently transformed to baclofen. The overall yield is 80%. ## INTRODUCTION AND DISCUSSION In order to develop a mass fragmentographi
## Abstract Two preparations of carbonβ14 labelled 4βaminoβ3β(4βchlorophenyl)βbutyric acid are described : First, the label is introduced in the 3βposition of the butyric acid chain in nine steps, starting from ^14^CO~2~. The total radiochemical yield is 30%, calculated from the first labelled inte