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ChemInform Abstract: Stereospecific Synthesis of (R)- and (S)-Baclofen and (R)- and (S)- PCPGABA (4-Amino-2-(4-chlorophenyl)butyric Acid) via (R)- and (S)-3-(4- Chlorophenyl)pyrrolidines.

✍ Scribed by S. YOSHIFUJI; M. KANAME

Book ID
112025799
Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
27
Category
Article
ISSN
0931-7597

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The synthesis of the title compound is described. It involves base catalyzed substitution of deuterium for hydrogen in 3-p- -chlorophenylglutaric acid which is subsequently transformed to baclofen. The overall yield is 80%. ## INTRODUCTION AND DISCUSSION In order to develop a mass fragmentographi

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A Simple and Efficient New Approach to the Total Synthesis of (Β±)-4-Amino-3-(4-chlorophenyl)-butyric Acid (Baclofen). -A new approach to the total synthesis of Baclofen (VI) involving the ( 2 + 2) cycloaddition between dichloroketene, generated from trichloroacetyl chloride (II), and olefin (I) as