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ChemInform Abstract: A Simple and Efficient New Approach to the Total Synthesis of (.+-.)-4- Amino-3-(4-chlorophenyl)-butyric Acid (Baclofen).

✍ Scribed by F. COELHO; M. B. M. DE AZEVEDO; R. BOSCHIERO; P. RESENDE

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 28
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199738241

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✦ Synopsis

A Simple and Efficient New Approach to the Total Synthesis of (±)-4-Amino-3-(4-chlorophenyl)-butyric Acid (Baclofen).

-A new approach to the total synthesis of Baclofen (VI) involving the ( 2 + 2) cycloaddition between dichloroketene, generated from trichloroacetyl chloride (II), and olefin (I) as the key step is reported. -(COELHO, F.; DE AZEVEDO,

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