A short synthesis of the taxotere side chain through dilithiation of Boc-benzylamine
โ Scribed by Kanazawa, Alice M.; Correa, Arlene; Denis, Jean Noel; Luche, Marie Jacqueline; Greene, Andrew E.
- Book ID
- 126023209
- Publisher
- American Chemical Society
- Year
- 1993
- Tongue
- English
- Weight
- 405 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
ilS.5R)-N-BOC-2,2-dinrethylI-phenyl-5-ox~oi~i~cu~oxy~ic acid 8 was prepared and efJiciently esterjied by conveniently pmtgted baccatins 9a,b. Smooth depmtection in formic acid gave the Ndepmtected intermediates of Taxotere and taxol. This C-2' und constitutes a pratical method to prepare
A highly enantioselective catalytic route to protected b-amino-a-hydroxy acids, such as the side chain of Taxotere, is presented. The organocatalytic asymmetric reactions between unmodified protected aoxyaldehydes and N-Boc-protected aryl imines give the corresponding compound with up to >19:1 dr an