A Short, Highly Efficient Synthesis of Coenzyme Q 10
β Scribed by Lipshutz, Bruce H.; Mollard, Paul; Pfeiffer, Steven S.; Chrisman, Will
- Book ID
- 120208541
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 49 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0002-7863
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π SIMILAR VOLUMES
Deuterium-labelled coenzyme Q 10 ([2-CD 3 -1 0 -CD 2 ]coenzyme Q 10 , coenzyme Q 10 -d 5 ) was synthesized by condensation of 2,3-dimethoxy-[5-CD 3 ]methyl-1, 4-hydroquinone with [1-CD 2 ]decaprenol. Five positions were selected for deuteration as replacement at these positions allowed examination o
## Abstract Radioβlabelled coenzyme Q~10~, labelled at the 3β²βposition with ^14^C, was synthesized starting from natural solanesol and ethyl [3β^14^C] acetoacetate. The radiochemical yield was 8.0% from ethyl [3β^14^C] acetoacetate. The specific radioactivity of the product was 44.8 ΞΌCi, 1.66 MBq/m
An improved route to coenzyme Q 10 (1) starting from commercially available coenzyme Q 1 is described. The key steps in this synthesis are the SeO 2 -mediated oxidation of the protected isoprenylhydroquinone 3 into the (E)-allyl alcohol 5 without the formation of undesired stereoisomer and the one-p