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A Short Catalytic Enantioselective Synthesis of the Proinflammatory Eicosanoid 12( R )-Hydroxy- 5( Z ),8( Z ),10( E ),14( Z )-eicosatetraenoic Acid (12( R )-HETE)

โœ Scribed by Han, Xiaojun; Corey, E. J.


Book ID
126111367
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
34 KB
Volume
2
Category
Article
ISSN
1523-7060

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A short,three-component total synthesis
โœ E.J. Corey; Keith Kyler; Natarajan Raju ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 226 KB

A highly effective synthesis of (k)-12-HETE (,l\_ ) from the components 2, 3 and 6 is described which employs a new class of cuprate reagents. \_N Y This compound, which is of biogenetic interest, [see E.