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A short,three-component total synthesis of 12-hydroxyeicosa-5,8,14(Z), 10(E)-tetraenoic acid (12-HETE) via the corresponding ketone

✍ Scribed by E.J. Corey; Keith Kyler; Natarajan Raju

Book ID: 104233903
Publisher: Elsevier Science
Year: 1984
Tongue: French
Weight: 226 KB
Volume: 25
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)81538-0

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✦ Synopsis

A highly effective synthesis of (k)-12-HETE (,l_ ) from the components 2, 3 and 6 is described which employs a new class of cuprate reagents. _N Y This compound, which is of biogenetic interest, [see E.

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