✦ LIBER ✦

A short and efficient synthesis of (S)-4-methylene proline benzyl ester from (S)-pyroglutamic acid

✍ Scribed by Sharad Kumar Panday; Dominique Griffart-Brunet; Nicole Langlois

Book ID: 104214683
Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 286 KB
Volume: 35
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)73465-4

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✦ Synopsis

S)-4-merhylene proline benzyl ester 2 was synthesized from benzyl N-terr -butoxycarbonyl pyroglutama~e through a Mannich and a Cope elimination reactions.

Racemic 4-methylene proline is a natural product which has heen isolated from seeds of loquat (Eriobotryajaponicu).l Optically pure Q-1, as structurally modified proline, has been described as potential enzyme inhibitor,293 particularly as inhibitor of proline dehydrogenase. 3 It has also been found to be useful as element of peptides and drugs4 such as tomaymycin analogs.4a

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