Pyroglutamic acid derivative (I) is proved to be an excellent chiral starting compound for the synthesis of title amino acids (IX), (X), and (V). The syntheses are based on a combination of methods previously used for the preparation of 4-and 5-substituted prolines. These methods are the ring openin
✦ LIBER ✦
New amino acids derived from L-pyroglutamic acid: Synthesis of Trans-4-benzyl-cis-5-phenyl-L-proline, L-α-(2-benzyl-3-phenylpropyl)-glycine and L-α-(3-phenylpropyl)-glycine
✍ Scribed by Jo Van Betsbrugge; Wim Van Den Nest; Patricia Verheyden; Dirk Tourwé
- Book ID
- 108378877
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 544 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0040-4020
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## Abstract The __García‐González__ reaction of D‐glucose and ethyl acetoacetate generated ethyl 5‐[(1′__S__)‐D‐erythrosyl]‐2‐methyl‐3‐furoate (**5**), which was converted to ethyl 5‐[(1′__R__)‐1′,4′‐dideoxy‐1′,4′‐imino‐D‐erythrosyl]‐2‐methyl‐3‐furoate (**3c**) and to ethyl 5‐[(1′__S__)‐1′,4′‐dideo
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