A short and efficient synthesis of (3S,4S)-4-[(tert-Butyloxycarbonyl)amino]-5-cyclohexyl-3-hydroxypentanoic acid ethyl ester
β Scribed by Schuda, Paul Francis; Greenlee, William J.; Chakravarty, P. K.; Eskola, Philip
- Book ID
- 120499123
- Publisher
- American Chemical Society
- Year
- 1988
- Tongue
- English
- Weight
- 429 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
The N-Boc dihydroxyethylene dipeptide isostere 7 and its N-Boc 3-(thiazol-4-ylJalany1 derivative 8 were synthesized, without purification of intermediates, from (4S~R)-22-dimethyl-4-(2-methy~propylJ-5-hydro~~thyl-l.3-dioxolane (361, in 24 and 32% overall yield, respectively, Alcohol 38 was readily p
## 5S)-2.3~,6-Tetrahydro-5-alkyl-N-(tert-butylo~carbonyl)-4~~-1 .I-oxarine-2-ones. which are readily prepared from optically pure 2-amino alcohols a&late selectively at the C-3 position to give (3S, SS)-dialkyl-2.35,6-tetrahydro-S-alkyl-N-(tertbutyloxycarbonyl)-4H-1.4-oxarine-2-ones in good yield. T